ANTIFUNGAL COMPOSITION FOR ORAL ADMINISTRATION COMPRISING ITRACONAZOLE AND METHOD FOR ITS PREPARING Russian patent published in 2003 - IPC

Abstract RU 2216323 C2

FIELD: pharmacy. SUBSTANCE: composition comprises mixture of itraconazole and phosphoric acid prepared by melting, pharmaceutically acceptable carrier and surface-active substance. The mass ratio of itraconazole to phosphoric acid is from 1 : 0.1 to 1 : 10. Composition provides the enhanced solubility of itraconazole in an aqueous solution from mixture prepared by melting as compared with solid intraconazole and the following enhancement of bioavailability of itraconazole in vitro. EFFECT: improved preparing method, enhanced and valuable medicinal properties of composition. 4 cl, 1 dwg, 1 tbl, 11 ex

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RU 2 216 323 C2

Authors

Voo Dzong Soo

Ji Khong Gi

Dates

2003-11-20—Published

2000-06-16—Filed