FIELD: medicine; pharmaceuticals.
SUBSTANCE: present invention relates to an amorphous solid dispersion comprising a tetrazole derivative of the formula (II) or (III) or a pharmaceutically acceptable salt thereof as an active ingredient and a water-soluble polymer, wherein the water-soluble polymer is hypromellose, which is included in an amount of 0.1 to 4 parts by weight, based on 1 part by weight of the active ingredient. Invention also relates to pharmaceutical P-glycoprotein inhibitors comprising an amorphous solid dispersion..
EFFECT: technical result: an amorphous solid dispersion comprises a tetrazole derivative of formula (II) or (III) having improved solubility and absorption rate, and thus can be effectively used to reduce multi-drug resistance (MDR) in cancer cells.
10 cl, 5 dwg, 8 tbl, 21 ex
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