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2 217 164

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IPC

(21) (22)

Application

2001129597/13, 2001-11-01

(24)

Start date

2001-11-01

(22)

Actual filing date

2001-11-01

(45)

Published

2003-11-27

(72)

Inventor

Bazhin M.A.Shamov V.V.Oshchepkov V.G.Okolelov V.I.Nevorotova G.P.

(73)

Holder

Vserossijskij Nauchno-Issledovatel'Skij Institut Brutselleza I Tuberkuleza Zhivotnykh

METHOD FOR PREPARING VACCINE AGAINST TUBERCULOSIS Russian patent published in 2003 - IPC

Abstract RU 2217164 C2

FIELD: veterinary microbiology, phthisiology. SUBSTANCE: invention relates to preparing dead cell-free (molecular) vaccine of new type. Method involves culturing mycobacteria from the strain BCG, isolation of two fractions cytoplasmic and fraction of cellular envelopes. Fraction of cellular envelopes is conjugated on cellulose matrix in the ratio = 1:10 (by mass) in the presence of chrome trichloride, then cytoplasmic fraction is added up to the protein content 1.5-2 mg/ml. Method provides preparing ecologically pure vaccine eliciting high immunogenicity. EFFECT: improved preparing method. 3 tbl, 4 ex

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RU 2 217 164 C2

Authors

Bazhin M.A.

Shamov V.V.

Oshchepkov V.G.

Okolelov V.I.

Nevorotova G.P.

Dates

2003-11-27—Published

2001-11-01—Filed