FIELD: medicine, phthisiology, immunology, vaccines.
SUBSTANCE: invention relates to the development of anti-tuberculosis vaccines of new generation and can be used in pharmaceutical industry and molecular pharmacology. Invention represents the composition for delivery and representing mycobacterium immunogens to the body immune system. Invention relates to artificial mycobacterial particles comprising the polynucleotide complex in the core (double-stranded RNA as a stimulating agent of nonspecific resistance of body, ds-RNA of killer yeast, Saccharomyces cerevisiae), and protein antigens of the vaccine starin BCG (the complete set) on surface as components of conjugate: spermidine-polyglucine. Inclusion of preparations of cytokines (γ-interferon and TNF-α) as components of anti-tuberculosis composition being exception of artificial mycobacterial particles results to the more expressed response of cellular link in immune system of mammalian body as compared with vaccine based on the BCG strain. The advantage of invention involves the enhanced specific activity of the preparation.
EFFECT: improved preparing method, valuable medicinal properties of composition.
6 cl, 4 dwg, 7 ex
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