METHOD FOR PREPARING 2-ALKYLIDENE-4-BROMOACETO- ACETIC ACID ESTER Russian patent published in 2003 - IPC

Abstract RU 2217412 C2

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to the improved method for preparing 2-alkylidene-4-bromoacetoacetic acid ester of the formula (3) wherein each R¹ and R² means independently each of other lower alkyl group with 1-5 carbon atoms that is used as an intermediate compound in preparing substances of pharmaceutical designation, for example, antibiotics. Method involves interaction of 4-bromoacetoacetic acid ester of the formula (1) wherein R¹ has above mentioned values with aldehyde of the formula (2): R²CHO wherein R² has above mentioned values in inert organic solvent in the presence of secondary amine and carboxylic acid. Method allows preparing the end product for a single stage with essentially high purity up to 96.4% and good yield up to 92%. EFFECT: improved preparing method, high purity and yield. 5 cl

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RU 2 217 412 C2

Authors

Kurimoto Isao

Nakamura Akikhiko

Khirata Norikhiko

Dates

2003-11-27—Published

1999-10-28—Filed