FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method for preparing acid salt of (Z)-2-aminithiazole compound of the formula (I) 
wherein R1 and R2 represent independently alkyl group comprising 1-5 carbon atoms; Y represents halogen atom; m represents valence of inorganic acid of the formula (III) HY given in description of invention and n represents whole number 1 or 2. Method involves interaction of 2-aminothiazole acid salt compound of the formula (II) 
wherein R1 and R2 represent alkyl group comprising 1-5 carbon atoms; X represents bromine or iodine atom and wavy line means that this compound is a mixture of E- and Z-isomers with inorganic acid of the formula HY (III) wherein Y represents halogen atom and wherein 2-aminothiazole acid salt compound of the formula (II) represents compound prepared by interaction of thiourea and halogenated compound of the formula (VI) 
wherein R1, R2, X and wavy line have the same values as determined above. Invention relates to continuous method for preparing preferably Z-isomer of 2-aminothiazole derivative hydrobromide of the formula (IV) 
wherein R1 and R2 represent independently lower alkyl group comprising 1-5 carbon atoms and wavy line means that this compound is a mixture of E- and Z-isomers including: continuous feeding thiourea and 2-alkylidene-4-bromoacetoacetic acid ester of the formula (V) 
wherein R1 and R2 have values determined above and wavy line means that this compound is a mixture of E- and Z-isomers into reaction vessel having at least one mixer, interaction of thiourea and compound of the formula (V) in reactor for time Rt that is sufficient for conversion of compound of the formula (V) to compound of the formula (IV) and removing reaction mixture containing compound of the formula (IV) from reaction vessel as effluent flow. Invention provides the realization of new method for preparing Z-isomer of 2- aminothiazole derivative hydrobromide. EFFECT: improved preparing method. 9 cl, 4 tbl
