HUMAN SEMAPHORIN L (H-SEMA-L) AND CORRESPONDING SEMAPHORINS IN OTHER SPECIES Russian patent published in 2003 - IPC

FIELD: medicine, biotechnology. SUBSTANCE: invention relates to human semaphoring L (H-Sema-L) and corresponding semaphorins in other species. Invention involves the development of new semaphorins that elicit immunomodulating properties. Proposed semaphorins of type L (Sema-L) comprise N-terminal signal peptide, typical Sema-domain and immunoglobulin-like domain at C-terminal region and hydrophobic domain that represents potential transmembrane domain. Invention relates to also nucleic acids encoding these semaphorins and to application of these semaphorins. The advantage of invention involves that new semaphorins elicit modulating properties. EFFECT: valuable biological properties of semaphorins. 20 cl, 8 dwg, 15 tbl, 11 ex