FIELD: genetic engineering, biotechnology, biochemistry, medicine, pharmacy.
SUBSTANCE: invention relates to DNA encoding glycoprotein VI (GP VI) used as a base for synthesis of recombinant GP VI by method of recombinant DNAs followed by its using for the development of pharmaceutical compositions possessing with capacity for inhibiting or blocking interaction of platelets with collagen. Using the invention provides preparing GP VI in the recombinant form and using this agent for therapeutic aims.
EFFECT: valuable medicinal properties of glycoprotein VI.
6 cl, 4 dwg, 6 ex
| Title |
Year |
Author |
Number |
| PROTEIN INHIBITING COLLAGEN-CAUSED AGGREGATION OF MAMMALIAN PLATELETS, RECOMBINANT PROTEIN INHIBITING COLLAGEN-CAUSED AGGREGATION OF PLATELETS, DNA FRAGMENT ENCODING RECOMBINANT PROTEIN, EXPRESSION VECTOR (VARIANTS), STRAIN OF CULTURED MAMMALIAN CELLS BHK - PRODUCER OF RECOMBINANT PROTEIN (VARIANTS), METHOD OF PREPARING RECOMBINANT PROTEIN, PHARMACEUTICAL COMPOSITION |
1992 |
- Kristiane Neske-Jungblut
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- Alekhandro Alagon
- Lurival' Domingos Possani
- Delia Anatolia Kevas-Agirre
|
RU2128705C1 |
| POLYPEPTIDE WITH BIOLOGICAL ACTIVITY OF INHIBITOR OF COLLAGEN-INDUCED ADHESION OF PLATELETS, ITS PREPARING AND USING |
2000 |
- Shtrittmatter Vol'Fgang
- Gjussov Detlef
- Khofmann Uve
- Khemberger Jurgen
- Fotef Zizi
- Shojble Bernkhard
|
RU2292351C2 |
| MODIFIERS OF GLYCOPROTEIN VI REPRESENTING NUCLEIC ACID |
2010 |
- Lehjzer Dzhuliana M.
- Raskoni Kristofer P.
- Bruks Duglas
- Zelenkofske Stiven L.
|
RU2571660C2 |
| PROTEIN BOUND WITH HUMAN GLYCOPROTEIN, COMPOSITION, PHARMACEUTICAL COMPOSITION, EXPRESSION VECTOR |
2016 |
- Bilalde Filip
- Zhanro-Perrus Martine
|
RU2773819C2 |
| POLYPEPTIDE, POSSESSING INHIBITING ACTIVITY WITH RESPECT TO PLATELET AGGREGATION AND/OR INHIBITING ACTIVITY WITH RESPECT TO PLATELET ADHESION, ENCODING IT POLYNUCLEOTIDE, COMPOSITION AND SET, CONTAINING SAID POLYPEPTIDE |
2006 |
|
RU2434941C2 |
| COMPOSITION, INHIBITING PLATELET AGGREGATION |
2006 |
- Josida, Sigeto
- Sudo, Tosiki
|
RU2557296C2 |
| ISOLATED HUMANIZED PROTEIN BINDING TO HUMAN GLYCOPROTEIN VI, ISOLATED ANTIBODY BINDING TO HUMAN GLYCOPROTEIN VI |
2018 |
- Bilalde, Filip
- Zhanro-Perrus, Martine
- Avenar, Zhiles
|
RU2778884C2 |
| PEPTIDE OR PEPTIDE COMPLEX BINDING TO alpha2- INTEGRIN, METHODS FOR PRODUCTION AND USE THEREOF |
2011 |
- Korvej Karsten
- Blum Khorst
- Kameron Beatris
- Dabdubi Tarik
- Dekari Stefani
- Boren Nikolya
- Papen David
- Lange Kristian
|
RU2588668C2 |
| INHIBITORS FOR USING IN HEMOSTASIS AND IMMUNE FUNCTION |
2000 |
- Sheppard Pol O.
- Lehsser Dzherald U.
- Bishop Pol D.
|
RU2239449C2 |
| THERAPEUTIC POLYPEPTIDES, HOMOLOGUES THEREOF, FRAGMENTS THEREOF AND APPLICATION THEREOF FOR MODULATION OF PLATELET-MEDIATED AGGREGATION |
2004 |
|
RU2524129C2 |
