FIELD: chemistry; biochemistry.
SUBSTANCE: invention relates to biotechnology, specifically to a method of identifying γ-secretase and its inhibitors and can be used in medicine when searching for active compounds for treating Alzheimer's disease. A genetic structure is formed, which codes fused protein, which contains a signal peptide and amino acid sequence GAIIGLMVGGVVIATVIVITLVML. In the obtained fused protein, except the GAIIGLMVGGVVIATVIVITLVML sequence, all sites acting as a signal for endo- or exocytosis, and/or protease splitting site are excluded.
EFFECT: invention allows for highly effective identification of γ-secretase or substances which inhibit its activity by reducing background signal and increasing specificity of the signal.
41 cl, 4 dwg, 17 ex
| Title |
Year |
Author |
Number |
| ADENO-ASSOCIATED VIRUS VECTOR FOR ALZHEIMER'S DISEASE TREATMENT, ITS APPLICATION FOR RECEPTION OF THERAPEUTIC AGENTS, AND ALSO METHOD OF ALZHEIMER'S DISEASE TREATMENT BY MEANS OF GIVEN VECTOR |
2004 |
- Tabira Takesi
- Khara Khideo
|
RU2335542C2 |
| MODIFICATION OF THE YEAST-2-HYBRID SYSTEM MAKING IT POSSIBLE TO TEST INTERACTIONS BETWEEN PROTEINS WITHIN MULTICOMPONENT PROTEIN COMPLEXES |
2021 |
- Belova Elena V.
- Georgiev Pavel G.
- Maksimenko Oksana G.
|
RU2762410C1 |
| PESTICIDE COMPOSITIONS AND RELATED METHODS |
2013 |
- Petolino Dzhozef
- Li Tszyantsyuan
- Evans Stiven L.
- Blyu Rajan S.
|
RU2662672C2 |
| INVENTION OF PROTEIN PI4KIIIA AND RELATED MEMBRANE PROTEIN COMPLEX IN TREATMENT OF ALZHEIMER'S DISEASE |
2016 |
- Huang Fude
- Zhang Xiao
- Wang Wenan
- Zhang Le
- Jiang Lixiang
- Zhu Tong
- Liu Haiyan
- Zhou Yudong
- He Yang
- Wei Wanguo
|
RU2724493C2 |
| PRODUCTION OF PEPTIES AND PROTEINS BY MEANS OF ACCUMULATION IN ENDOPLASMIC RETICULUM OF PLANTS |
2002 |
- Ljudevid Mugika Marija Dolores
- Torrent Ketglas Margarita
- Lasser-Ramassami Sabina
|
RU2381275C2 |
| DNA SEQUENCE ENCODING POLYPEPTIDE THAT BINDS WITH MORT-1 (VARIANTS), POLYPEPTIDE (VARIANTS) AND METHOD FOR ITS PREPARING, VECTOR, METHOD FOR MODULATING LIGAND FAS-R OR TNF EFFECT ON CELLS (VARIANTS), METHOD FOR TREATMENT OF CELLS, METHOD FOR ISOLATION AND IDENTIFICATION OF PROTEINS, METHOD FOR MODULATING MORT-1-INDUCED EFFECT OR MORT-1-BINDING PROTEIN-INDUCED EFFECT ON CELLS |
1996 |
- Vollakh Dehvid
- Boldin Mark
- Goncharov Tanja
- Gol'Tsev Jurij
|
RU2235779C2 |
| MODIFIED SIGNAL PEPTIDE OF ESCHERICHIA COLI ENTEROTOXIN-II AND MICROORGANISM EXPRESSING FUSION PROTEIN OF MENTIONED PEPTIDE WITH HETEROLOGICAL PROTEIN |
1999 |
- Kvon Se Chang
- Dzung Sung Joub
- Skhin Khoon
- Choj Dzaj Do
- Choj Ki Doo
- Li Gvan Sun
|
RU2198179C2 |
| IMMUNITY INDUCING AGENT |
2009 |
- Okano Fumiesi
- Simidzu Masaki
- Saito Takanori
|
RU2511039C2 |
| NUCLEIC ACID SYNTHETIC MOLECULE (VERSIONS), MAMMAL CELL EXPRESSION VECTOR, MAMMAL HOST CELL AND METHOD OF EXPRESSING ANTIGEN PROTEIN OF HUMAN EPIDERMAL GROWTH FACTOR-2 (HER2/neu) OR SHORTENED FORM THEREOF |
2004 |
- Gallo Paskual'
- Monachi Paolo
- Nutstso Mauritsio
|
RU2397249C2 |
| IMMUNITY INDUCING AGENT |
2013 |
- Okano Fumiesi
- Simidzu Masaki
- Saito Takanori
|
RU2639518C2 |
