FIELD: biochemistry.
SUBSTANCE: invention relates to mutant semaphorin 3 or its functional fragment, to a hybrid protein containing said semaphorin 3 or its functional fragment, as well as to a method for production thereof. Also disclosed is a nucleic acid molecule encoding said mutant semaphorin 3 or a functional fragment thereof, a nucleic acid molecule encoding said hybrid protein, as well as a vector and a host cell containing said nucleic acid molecule. Invention also relates to a pharmaceutical composition comprising said mutant semaphorin 3 or a functional fragment thereof, a fusion protein and/or a nucleic acid molecule, as well as to use of said mutant semaphorin 3 or its functional fragment, a hybrid protein, nucleic acid molecules, a vector, a host cell, a pharmaceutical composition for treating angiogenic disorder and for treating a malignant disease.
EFFECT: invention enables effective treatment of angiogenic disorder and tumor disease.
53 cl, 4 tbl, 2 ex, 13 dwg
