DERIVATIVES OF PHENYL- AND AMINOPHENYLALKYLSULFONAMIDE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new derivatives of phenyl- and aminophenylalkylsulfonamide of the formula: wherein A means (R¹SO₂NR²-), (R³R⁶⁰NSO₂NR²-); X means -NH-, -CH₂- or -OCH₂-; Y means 2-imidazoline, 2-oxazoline or 4-imidazole; R¹ means (lower)-alkyl or phenyl; each of R², R³, R⁶⁰ means independently each of other means hydrogen atom, (lower)-alkyl or phenyl; each of R⁴, R⁵, R⁶, R⁷ independently each of other means hydrogen atom, (lower)-alkyl, -CF₃, (lower)-alkoxy-group, halogen atom, phenyl, (lower)-alkenyl, hydroxyl, (lower)-alkylsulfonamide or (lower)-cycloalkyl wherein R² and R⁷ in common can form optionally alkylene or alkenylene with 2-3 carbon atoms in unsubstituted or optionally substituted 5- or 6-membered ring wherein optional substituents in ring are halogen atoms, (lower)-alkyls or -CN under condition that when R⁷ means hydroxyl or (lower)-alkylsulfonamide then X doesn't mean -NH- when Y means 2-imidazoline. Invention relates also to pharmaceutically acceptable salts and to pharmaceutical composition based on thereof designated for regulation of physiological phenomena associated with substances eliciting affinity to α_1A/1L-adrenoceptors. Invention provides preparing new biologically active compounds and medicinal agents based on thereof for using in medicine. EFFECT: valuable medicinal properties of compounds. 16 cl, 5 tbl, 18 ex