DERIVATIVES OF THIAZOLE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to novel derivatives of thiazole of the formula (I) wherein R¹ means group of formulas: (a) , (b) , (c) and (d) wherein R² means group of the formula (II) ; R³ means hydrogen atom, alkyl, cycloalkyl and so on; R⁴ means alkyl, phenyl, heteroaryl; R⁵ and R⁶ each independently each of other means hydrogen atom, heteroaryl; R⁷ and R⁸ each independently each of other means hydrogen atom; or R⁷ and R⁸ in common with nitrogen atoms with which they are bound form 5-6-membered heterocycle; R⁹ means hydrogen atom, alkyl, cycloalkyl; R¹⁰ means phenyl, benzyl and so on; A means carbonyl or sulfonyl; B means hydrogen atom; each among a-m means 0 or positive number from 0 to 2 but not 0 when R¹ means -NH₂; b means number from 0 to 4; c, d, f, g, k, l and m each independently each of other means 0 or 1 and therefore each among c, f and g can't mean simultaneously 0 and owing to m doesn't mean 0 when f or g mean 1; i means 0; e means number from 0 to 3; h means number from 0 to 5; j means number from 0 to 2 and sum e, h and j = 2-7; and their pharmaceutically acceptable salts. Invention relates also to derivatives of thiazole of the formula (XXXI) wherein and a have values indicated above and wherein R³ doesn't mean hydrogen atom or methyl when R¹ means group (e) , (f) . Invention relates also to method for preparing compound of the formula (I) by interaction of compound of the formula (XXXI) with amine of the formula (III) given in description of invention. Invention relates also to pharmaceutical composition eliciting properties to inhibit binding adhesive proteins and containing compound of the formula (I) and therapeutically inert carrier. Invention provides preparing the new compound eliciting properties to inhibit binding adhesive protein. EFFECT: improved preparing method, valuable medicinal properties of compounds. 20 cl, 1 tbl, 176 ex