QUINOLINE/BENZOXAZINONE DERIVATIVES AND THEIR APPLICATION Russian patent published in 2008 - IPC C07D215/22 C07D405/06 C07D265/36 C07D223/16 A61K31/4704 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention concerns organic chemistry and describes compounds of the general formula (I): and their pharmaceutically acceptable salts, where m ranges within 0 to 1; p ranges within 1 to 3; q is 2; r is 2; A is an optionally substituted arylene or optionally substituted heteroarylene, where "optionally" denotes that the said groups can be substituted by 1-4 substituents, preferably 1 or 2 substituents selected out of a group including alkyl, cycloalkyl, cycloalkoxy group, cycloalkylalkyl, heteroalkyl, hydroxyalkyl, halogen, nitro group, cyano group, hydroxyl group, alkoxy group, amino group, acylamino group, monoalkylamino group, dialkylamino group, halogenalkyl, halogenalkoxy group, heteroalkyl, -COR (where R is hydrogen, alkyl, phenyl or phenylalkyl), -(CR'R")_n-COOR (where n is an integer ranging within 0 to 5, R' and R" are independently hydrogen or alkyl, and R is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl), or (CR'R")_n-CONR^a'R^b' (where n is an integer ranging within 0 to 5, R' and R" are independently hydrogen or alkyl, and R^a' and R^b' are independently hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenyl or phenylalkyl); E is N; X is O, S or -CR^aR^b -, where R^a and R^b are independently hydrogen or alkyl; all R¹ are independently halogen or alkoxy group; Y is -(CR²R³)_n-, where n is 1 or 2 and R² and R³ are independently hydrogen or alkyl, or X and Y together form alkenylene group; R⁴, R⁵, R⁶, R⁷, R⁸, and R⁹ are independently hydrogen or alkyl; and R¹⁰ is hydrogen, alkyl, arylalkyl, aryloxyalkyl, heteroaryl or heterocyclyl. The invention also concerns pharmaceutical composition based on compounds of the formula (I), with modulation effect on 5-HT6.

EFFECT: obtaining new quinoline and benzoxazinone derivatives with useful biological properties.

11 cl, 1 tbl, 6 ex