METHOD OF PRODUCING 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS Russian patent published in 2012 - IPC C07D417/14 A61K31/496 A61P29/00 A61P35/00 A61P37/00 

Abstract RU 2456285 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing compounds of formula I The method is realised via cyclisation of a compound of formula (IV) with an intermediate compound Int4 at room temperature to obtain a compound of formula (III), reducing the nitro group in the compound of formula (III) to obtain a compound of formula (II). Further, by bonding the compound of formula (II) to a compound of formula Int5 in an aprotic solvent, a compound of formula (I) is obtained (structural formulae of compounds (II), (III), (IV), Int4, Int5 are given in the claim).

EFFECT: improved method of producing compounds of formula (I).

25 cl, 3 dwg, 4 ex

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RU 2 456 285 C2

Authors

Mussi Alen

Rezhino Filipp

Bellami Fransua

Lerme Ann

Dates

2012-07-20Published

2008-02-13Filed