FIELD: organic chemistry, steroids. SUBSTANCE: invention relates to conjugate of [19-nor-17α-ethynyl-17β-hydroxy- pregna-1,3,5(10)-triene-3-yl] -oxyacetic acid with bovine serum albumin of the general formula (I) 17α- wherein n = 9-21 prepared by treatment of ethynylestradiol with bromoacetic acid ethyl ester in the presence of alkali and conversion of [19-nor-17β-ethynyl-17α--hydroxy-pregna-1,3,5(10)-triene-3-yk]-oxyacetic acid to the mixed anhydride using isobutylchlorocarbonate and the following amidation of bovine serum albumin with indicated anhydride. Conjugate shows specificity and sensitivity for immunochemical method for determination of ethynylestradiol (I) in physiological fluids and tissues of animals. EFFECT: improved determination method.
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PREPARING ORTHO-ARYLGLYCOLIC ACIDS | 2002 |
|
RU2214995C1 |
CONJUGATE OF 4-[1-ETHYL-2-(4-HYDROXYPHENYL)-BUTENE-1-YL]-PHENYLACETIC ACID WITH BOVINE SERUM ALBUMIN FOR IMMUNOCHEMICAL METHOD OF DETERMINATION OF DIETHYLSTILBOESTROL | 2002 |
|
RU2218352C1 |
PHARMACEUTICAL COMPOSITIONS CONTAINING DERIVATIVES OF ESTRA-1,3,5(10)-TRIENE | 1995 |
|
RU2179442C2 |
DERIVATIVES OF ESTRA-1,3,5(10)-TRIENE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2139885C1 |
SULFAMATE DERIVATIVES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS | 1996 |
|
RU2159774C2 |
METHOD OF SYNTHESIS OF SUCCINIC ACID MONOETHER FROM 17-HYDROXYSTEROID AND SUCCINIC ANHYDRIDE | 2001 |
|
RU2193566C1 |
15β-SUBSTITUTED STEROIDS WITH SELECTIVE OESTROGENIC ACTIVITY | 2005 |
|
RU2386637C2 |
17α-ALKYL-17β-HYDROXYESTRATRIENES, THEIR USING AND PHARMACEUTICAL PREPARATION | 2002 |
|
RU2285009C2 |
17 β -OXYESTRATRIENES | 2002 |
|
RU2339643C2 |
COMPOUNDS, SET, ANDROGENIC COMPOSITION | 2000 |
|
RU2242479C2 |
Authors
Dates
2003-12-10—Published
2002-06-19—Filed