SULFAMATE DERIVATIVES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS Russian patent published in 2000 - IPC

FIELD: pharmaceutical chemistry. SUBSTANCE: invention provides sulfamate derivatives of 1,3,5(10)-extratriene derivatives having general formula I: (I), in which R¹ is -COR³,-COOR⁴,-CONR⁵R⁶,-SO₂R⁴, or -SO₂NR⁵R⁶ wherein R³ and R⁴ independently denote C1-C5-alkyl, C3-C5-cycloalkyl, or phenyl, and R⁵ and R⁶ independently denote C1-C5-alkyl; R² is hydrogen atom or C1-C5-alkyl; R⁷ and R⁸, independently from each other, are hydrogen atom or alkoxy group; R⁹ and R¹⁰ are hydrogen atom or, together with each other, form one methylene group; R¹¹,R¹², and R¹³, independently from each other, are hydrogen or hydroxyl group optionally esterified by physiologically acceptable inorganic or organic acids, or R¹² and R¹³ are alkynyl with up to 5 carbon atoms, provided that R⁸,R¹¹, and R¹², independently from each other, are located in alpha- or beta positions. Compounds I show estrogenic activity. EFFECT: extended assortment of estrogenic preparations. 26 cl, 2 tbl