STEROID DERIVATIVES, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION, TREATMENT METHOD, METHOD FOR SUPPRESSION OF MICROORGANISMS GROWTH Russian patent published in 2003 - IPC

FIELD: organic chemistry, steroids, chemical technology, pharmacy. SUBSTANCE: invention describes some new steroid derivatives of the formula (I) wherein R₃,R₇,R₁₂ represent independently OH, =O, C_1-10-hydroxyalkyl, optionally substituted C_1-10-aminoalkyl, possibly protected C_1-10-hydroxyalkyloxy-group wherein OH-group is protected possibly, C_2-10-acyloxy-group, possibly substituted C_1-10-aminoalkyloxy-group, possibly substituted C_1-10-aminoalkylcarboxy-group wherein amino-group is possibly protected or quaternized, H₂N- HC(Q5)-C(O)-O- wherein Q5-side chain of any amino acid and amino-group is possibly protected, possibly substituted C_1-10-guanidinoalkyloxy-group, C_2-10-alkenyloxy-group, C_1-10-cyanoalkyloxy-group, C_1-10- azidoalkyloxy-group; R₁₇ is possibly substituted C_1-10-hydroxyalkyl wherein OH is optionally protected or optionally substituted C_1-10-alkyloxy-C_1-10-alkyl, optionally substituted C_1-10-aminoalkyl, C_2-10-acyl or its ketal derivatives, or binding group bound to the second steroid at position 17 wherein binding group represents C_1-10- alkyleneoxy-C_1-10-alkylene, or their pharmaceutically acceptable salts. Proposed compounds are antibacterial agents providing sensitivity of microorganisms (sensibilization) to effect of other antibiotics, among them erythromycin and novobiocin. EFFECT: improved preparing method, enhanced treatment method, valuable medicinal properties of compounds. 37 cl, 7 sch, 8 tbl, 8 ex