METHODS FOR TREATING INFLAMMATION, AUTOIMMUNE DISORDERS AND PAIN Russian patent published in 2018 - IPC A61K31/575 A61K38/38 A61P29/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, namely, to therapy, and is intended for gene modulation related to inflammation. For treating, reducing, or preventing acute or chronic inflammations and pains related to disease or symptom selected from oral mucositis, gingivitis, periodontitis, gastritis, colitis, ileitis, Crohn's disease, chronic inflammatory bowel disease, inflammatory bowel syndrome, chronic inflammatory bowel disease, gluten disease, ulcerative colitis, gastric ulcer, peptic ulcer, buccal ulcer, nasopharyngeal ulcer, esophageal ulcer, duodenal ulcer, gastrointestinal ulcer, cystic fibrosis or autoimmune disorder; identify the patient with the disease or symptom of the disease. Next, a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA) from the compound of Formula (III), or pharmaceutically acceptable salt thereof is administrated to a patient that needs that. This CSA modulates the genes related to inflammation, treating, reducing, or preventing acute or chronic inflammations and pains related to disease or symptom of the disease:

(III), where R₃, R₇, R₁₂ and R₁₈ are independently selected from the group consisting of aminoalkyloxy, aminoalkylcarboxy, alkylaminoalkyl, alkoxycarbonylalkyl, alkylcarbonylalkyl, di(alkyl)aminoalkyl, alkyloxycarbonylalkyl, alkylcarboxyalkyl and hydroxyalkyl.

EFFECT: use of a group of inventions makes it possible to increase the effectiveness of treatment, reducing or prevention of acute or chronic inflammation and pain related to said diseases or symptoms of the disease.

25 cl, 3 tbl, 1 ex