SULFONAMIDE-SUBSTITUTED ANNELATED SEVEN-MEMBERED CYCLIC COMPOUNDS, THEIR USING AS MEDICINAL AGENT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to sulfonamide-substituted annelated seven-membered compounds of the formula (I): wherein X(1) means -O- or -CH₂-; X(2) and X(3) mean -CH₂-; X(4) means -CH₂- or -CHOH-; Y(1), Y(2), Y(3) and Y(4) mean independently of one another CR(12)-; R(12) mean independently of one another hydrogen, fluorine, chlorine, bromine, iodine atom, (C₁-C₅)-alkyl, CN, NO₂, -Z-C_mH_2m-R(13) wherein Z means oxygen atom or CONR(14); R(14) means hydrogen atom or (C₁-C₃)- alkyl; m = 0, 1, 2, 3, 4 or 5; R(13) means hydrogen atom or unsubstituted phenyl or phenyl substituted with methoxy-group; R(3) means R(17)-C_xH_2x wherein x = 1, 2, 3, 4, 5; R(17) means hydrogen atom; or R(3) means unsubstituted phenyl or phenyl substituted with 1 or 2 substituents taken among group including fluorine, chlorine, bromine atom, (C₁-C₂)-alkyl or methoxy-group; R(4) means hydrogen atom or R(20)-C_rH_2r wherein r = 1, 2, 3, 4, 5, 6; R(20) means hydrogen atom; R(5) means hydrogen atom in all their stereoisomeric forms and as mixtures in any ratios and their physiologically acceptable salts also. Compounds of the formula (I) show effect blocking K⁺-channel and can be used in pharmaceutical composition for preparing medicinal agent for treatment or prophylaxis of stomach and alimentary tract ulcers, reflux esophagitis and diseases associated with diarrhea. EFFECT: valuable medicinal properties of compounds. 17 cl, 21 ex