SULFONAMIDE-SUBSTITUTED ANNELATED FIVE-MEMBERED CYCLIC COMPOUNDS, USING THEIR AS MEDICINAL AGENT AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new sulfonamide-substituted annelated five-membered cyclic compounds of the general formula (I): wherein: R(1), R(2) mean hydrogen atom; R(3) means R(10b) -C_nH_2n wherein n = 0, 1; R(10b) means methyl; R(4) means R(13) -C_rH_2r, wherein r = 0, 1, 2, 3, 4, 5, 6; R(13) means methyl, nitrogen- containing aromatic 6-membered heterocycle; R(5), R(6), R(7), R(8) mean independently of one another hydrogen, fluorine, chlorine, bromine, iodine atom, -NO₂, -Y-C_sH_2s- R(18) wherein Y means O-; s = 1, 2, 3, 4, 5, 6; R(18) means hydrogen atom, methyl; X means CR(22)R(23)-, -SO₂- wherein R(22), R(23) means hydrogen atom or methyl and their physiologically acceptable salts also. Compounds of the formula (I) inhibit K⁺-channel and can be used in pharmaceutical composition for treatment and prophylaxis of diseases mediated by K⁺-channels. EFFECT: valuable medicinal properties of compounds. 14 cl, 14 ex