DERIVATIVES OF VITAMIN D, METHOD FOR THEIR PREPARING, INTERMEDIATE COMPOUNDS Russian patent published in 2004 - IPC

FIELD: organic chemistry, chemical technology, vitamins. SUBSTANCE: invention relates to new derivatives of vitamin D of the general formula (I): wherein Y₁ means hydroxy-group, C_1-12-alkanoyloxy-group or optionally substituted benzoyloxy-group; Y₂ means hydrogen atom, C_1-12-alkanoyl or optionally substituted benzoyl group; R₁ and R₂ form along with exocyclic methylene group; R₃ and R₄ mean independently hydrogen atom, C_1-4-alkyl; Q means C_1-3-alkylene substituted possibly substituted at α- or β- position with hydroxy-group that, in turn, can be esterified; R₅ and R₆ mean simultaneously C_1-4-alkyl; or R₅ and R₆ along with carbon atom C-25 form cyclopropyl group; Z means 5-membered aromatic carbo-or heterocycle, such as phenyl, oxazole, thiazole, furan, thiophene, pyrrole, isoxazole, pyrazole, triazole, pyridine, pyrimidine, possibly substituted C_1-12-alkylone. Compounds of the formula (I) are useful against diseases caused by hyperproliferation and loss differentiation in cells. EFFECT: improved preparing method, valuable biological and medicinal properties of compounds. 9 cl, 29 ex