9,10-SECOPREGNANE DERIVATIVE AND PHARMACEUTICAL AGENTS Russian patent published in 2012 - IPC C07C401/00 A61K31/59 A61P17/06 

FIELD: chemistry.

SUBSTANCE: invention describes a novel useful vitamin D₃ derivative, which has excellent vitamin D₃ activity, and has relatively low action on system calcium metabolism compared to other traditional vitamin D₃ derivatives. The invention includes a 9,10-secopregnane derivative of general formula [1] and a pharmaceutical composition containing said derivative as an active ingredient. [Formula 1]

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In general formula [1], the next part of the structure between position 16 and position 17 denotes a single bond or a double bond. Y denotes a single bond, alkylene, alkenylene or phenylene; R¹ and R² are identical or different and each denotes hydrogen, alkyl or cycloalkyl; or R¹ and R², taken together with an adjacent carbon atom, form a cycloalkyl; R³ denotes hydrogen or methyl; Z denotes hydrogen, hydroxy or -NR¹¹R¹², where R¹¹ and R¹² assume values given in the claim.

EFFECT: obtaining a useful D₃ derivative.

14 cl, 73 ex, 8 tbl