OBESITY TREATMENT Russian patent published in 2004 - IPC

FIELD: organic chemistry, peptides, medicine, pharmacy. SUBSTANCE: invention relates to peptide that comprises analogue of the growth hormone carboxy-terminal sequence wherein carboxy-terminal sequence comprises the following amino acid residues 177-191 of the human growth hormone: Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe or corresponding sequence of growth hormone distinctive from the human mammal growth hormone wherein in indicated analogue amino acids at positions 182 and 189 of the human growth hormone are bound by a bond in order to promote the formation of cyclic conformation; and/or amino acids at positions 183 and 186 of the human growth hormone are bound by saline bridge or covalent linkage' or its salts with organic or inorganic acid. Compounds are able to reduce body mass and lipid mass in mammals with obesity. Invention describes also method for treatment of obesity in animal involving administration to mammal the proposed peptide and pharmaceutical composition containing indicated peptide. EFFECT: valuable medicinal properties of peptide. 15 cl, 8 tbl, 21 dwg, 1 ex