LONG-ACTING POLYPEPTIDES AND METHODS OF THEIR PREPARATION AND ADMINISTRATION Russian patent published in 2021 - IPC A61K38/27 

FIELD: organic chemistry.

SUBSTANCE: group of inventions relates to the use of a modified carboxy-terminal peptide (CTP) polypeptide of chorionic gonadotropin in maintaining and/or increasing the level of insulin-like growth factor (IGF-1) to the normal therapeutic range in a subject who is a child, and said CTP-modified growth hormone is administered once a week at a dose of 0.66 mg/kg/week. EFFECT: group of inventions provides a long half-life while maintaining high pharmacological efficacy, increased stability in the blood serum, high activity and low probability of inducing undesirable immune responses in the subject.

19 cl, 11 ex, 23 tbl, 39 dwg