ALPHA-ARYL-N-ALKYLNITRONES, PHARMACEUTICAL COMPOSITIONS (VARIANTS), METHOD FOR INHIBITION OF NEURODEGENERATIVE DISEASES, METHOD FOR TREATMENT AND METHODS FOR PROPHYLAXIS (VARIANTS) Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new α-aryl-N-alkylnitrones of the formula (I) or (II), pharmaceutical compositions based on thereof, method for inhibition of neurodegenerative diseases, in particular, such as Alzheimer's disease, method for treatment of autoimmune diseases and methods for prophylaxis of arising autoimmune and inflammatory states of nervous system in mammals using compounds of the formula (I) or (II). Indicated compounds can be used also as analytic reagents for detection of free radicals. Compounds of the formula (I) and (II) correspond to general formula (I) and (II) wherein R¹ is taken among group comprising C₁-C₁₀-alkoxy, C₁-C₁₀-alk-C₆-C₁₄-aryloxy, C₁-C₁₀-alk-C₃-C₁₀-cycloalkoxy, C₆-C₁₄-aryloxy and C₃-C₁₀- cycloalkoxy; R² is taken among group comprising hydrogen atom, C₁-C₁₀-alkoxy, C₁-C₁₀-alk-C₃-C₁₀-cycloalkoxy, C₃-C₁₀-cycloalkoxy and halogen atom; or when R¹ and R² are bound to adjacent carbon atoms then R¹ and R² can be combined in common to form C₁-C₁₀-alkylenedioxy-group; R³ is taken among group comprising hydrogen atom, C₁-C₁₀-alkoxy, C₁-C₁₀-alk-C₃-C₁₀-cycloalkoxy, C₃-C₁₀-cycloalkoxy and halogen atom; R⁴ is taken among group comprising hydrogen atom and C₁-C₁₀-alkyl; R⁵ is taken among group comprising C₃-C_10/ -alkyl, halogen-substituted C₃-C₁₀-alkyl and C₃-C₁₀-cycloalkyl; R⁶ is taken among group comprising alkoxy-group comprising from 1 to 8 carbon atoms, alkaryloxy-group comprising from 7 to 10 carbon atoms and aryloxy-group comprising from 6 to 10 carbon atoms; R⁷ is taken among group comprising alkoxy-group comprising from 1 to 8 carbon atoms and fluorine atom; or when R⁶ and R⁷ are bound to adjacent carbon atoms then R⁶ and R⁷ can be combined in common to form alkylenedioxy- group comprising from 1 to 6 carbon atoms; R⁸ is taken among group comprising hydrogen atom and alkoxy-group comprising from 1 to 8 carbon atoms; R⁹ is taken among group comprising alkyl comprising from 3 to 8 carbon atoms, halogen-substituted alkyl comprising from 3 to 8 carbon atoms and cycloalkyl comprising from 3 to 10 carbon atoms. Above indicated cycloalkyl and cycloalkoxy-group can comprise one or some cyclic rings. EFFECT: improved treatment and prophylaxis methods, valuable medicinal properties of compounds. 47 cl, 2 tbl, 1 dwg, 97 ex