FIELD: organic chemistry, biotechnology, pharmacy. SUBSTANCE: invention relates to manufacturing antiviral compounds. Method for preparing ribavirin involved enzymatic trans-glycosylation reaction of 1,2,4-triazole-3-carboxamide followed by isolation of the end product. The trans-glycosylation reaction is carried out in the presence of recombinant purine-nucleoside phosphorylase from E. coli BL21 (DE3)/pERPUPHO1 immobilized on the aminopropylated silochrome. Method provides simplifying technology and using enzyme for 15 industrial cycles. EFFECT: improved preparing method. 4 dwg, 2 ex
| Title |
Year |
Author |
Number |
| METHOD OF PRODUCING 1-β-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDE |
2011 |
- Konstantinova Irina Dmitrievna
- Fateev Il'Ja Vladimirovich
- Miroshnikov Anatolij Ivanovich
|
RU2480218C1 |
| METHOD FOR PRODUCTION OF PURINE NUCLEOSIDES OF β-D-ARABINOFURANOSE SERIES |
2015 |
- Konstantinova Irina Dmitrievna
- Fateev Ilya Vladimirovich
- Miroshnikov Anatolij Ivanovich
|
RU2624023C2 |
| METHOD OF PRODUCING RECOMBINANT PURINE NUCLEOSIDE PHOSPHORY-LASE, RECOMBINANT PLASMID DNA PERPUPHO1 AND STRAIN ESCHERICHIA COLI BL21(DE3)PERPUHO1 FOR ITS REALIZATION |
2000 |
- Esipov R.S.
- Gurevich A.I.
- Miroshnikov A.I.
- Chuvikovskij D.V.
|
RU2179188C2 |
| NEW 1-(-D-RIBOFURANOSIL-3-(5-SUBSTITUTED-1,2,4-OXADIAZOLE-3-YL)-1,2,4-TRIAZOLES WITH ANTI-VIRAL PROPERTIES AND METHOD FOR THEIR PRODUCTION |
2016 |
- Chudinov Mikhail Vasilevich
- Zhurilo Nikolaj Ilich
- Matveev Andrej Valerevich
|
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| METHOD OF PRODUCING CLADRIBINE BY ENZYMATIC TRANSGLYCOSYLATION OF 2-CHLORO-6-AZIDOPURINE WITH SUCCESSIVE TWO-STEP CONVERSION OF AZIDO GROUP |
2023 |
- Alekseev Kirill Sergeevich
- Kurochkin Nikolaj Nikolaevich
- Drenichev Mikhail Sergeevich
- Borokh Valentina Nikolaevna
- Danilova Klavdiya Vasilevna
- Varga Mikhail Andreevich
|
RU2836333C1 |
| METHOD OF PRODUCING COMPLEX ENZYMIC PREPARATION OF ACETOKINASE AND ADENYLATKINASE FROM E.COLI BIOMASS |
0 |
- Feofanov S.A.
- Zagrebelnyj S.N.
- Zakabunin A.I.
- Romanov V.P.
|
SU837066A1 |
| 5-(TETRAHYDROFURAN-2-YL)-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID AMIDE WITH ANTIVIRAL ACTIVITY, AND METHOD FOR PRODUCTION |
2016 |
- Konstantinova Irina Dmitrievna
- Chudinov Mikhail Vasilevich
- Prutkov Aleksandr Nikolaevich
- Matveev Andrej Valerevich
- Grebenkina Lyubov Evgenevna
- Dorofeeva Elena Viktorovna
|
RU2624018C2 |
| 7-METHYL-2'-DEOXYGUANOSINE HYDROIODIDE SALT AS SUBSTRATE FOR PRODUCING 2'-DEOXYNUCLEOSIDES BY METHOD OF ENZYME TRANSGLYCOSYLATION |
2017 |
- Alekseev Kirill Sergeevich
- Drenichev Mikhail Sergeevich
- Mikhajlov Sergej Nikolaevich
|
RU2664472C1 |
| 1-(2-OXYETHOXYMETHYL)-1,2,4-TRIAZOLE-5-CARBOXAMIDE POSSESSING ACTIVITY AGAINST HERPES VIRUS |
0 |
- Galegov G.A.
- Linitskaya G.L.
- Krojcha Yu.G.
- Tsilevich T.L.
- Zavgorodnij S.G.
- Florentev V.L.
|
SU1124559A1 |
| METHOD OF PRODUCING RIBO- AND DESOXYRIBONUCLEOSIDE-5Ъ-TRIPHOSPHATES TAGGED WITH 14C AND 3H ISOTOPES |
0 |
- Feofanov S.A.
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- Chudinov A.R.
|
SU1251509A1 |
