FIELD: biotechnology.
SUBSTANCE: invention relates to new antiviral derivatives of general formula:
,
where R is selected from H, CH3, CH(CH3)2, Ph, as well as to a process for their preparation that can be used in the pharmaceutical industry. The proposed production method involves introduction of isopropylidene and triphenylmethyl protecting groups into the glycosidic portion of ribavirin, dehydration of the carboxamide group into amidoxime, preparation of an O-acylated derivative with an amidoxime moiety followed by intramolecular cyclization to obtain a glycosidically protected ribavirin analogue having a 5-substituted-1,2,4-oxadiazole fragment at the 3rd position of 1,2,4-triazole, and subsequent removal of the isopropylidene and trimethylphenyl protecting groups.
EFFECT: new compounds effective against herpes simplex virus type 1, influenza A virus and hepatitis C virus, as well as an effective way of their preparation, are proposed.
3 cl, 12 ex, 6 dwg
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