FIELD: chemistry.
SUBSTANCE: invention relates to biotechnology. The method of producing 1--D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) involves reaction of excess guanosine with 1,2,4-triazole-3-carboxamide in a potassium phosphate buffer in the presence of sodium arsenate and purine nucleoside phosphorylase.
EFFECT: invention enables 100% conversion of guanosine to guanine and simplifies the process of separating the end product from the reaction mixture.
3 dwg, 1 tbl, 1 ex
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| METHOD FOR PREPARING 1-β-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDE (RIB AVIRIN) | 2002 |
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