SULFONYLOXAZOLAMINES AS THERAPEUTICALLY ACTIVE COMPOUNDS Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to sulfonyloxazoloamines of the general formula (I):

wherein each R¹ and R² means independently of one another hydrogen atom, A, -(CH₂)_n-Ar; or R¹ and R² both in common represent mononuclear saturated heterocycle with nitrogen atom; Z means hydrogen atom, A, CF₃, Hal or OA; A means alkyl with 1-6 carbon atoms; Ar means phenyl mono- or disubstituted with a substituent Z under condition that Z can not mean hydrogen atom; Hal represents F, Cl or J; n = 1 or 2; or their physiologically acceptable salts or solvates. The application of compounds of the formula (I) wherein R¹ means hydrogen atom or A; R² means A or -(CH₂)_n-Ar; or R¹ and R² represent in common mononuclear saturated heterocycle with nitrogen atom; Z means hydrogen atom or A; A means methyl; Ar means unsubstituted phenyl; n = 1, or their physiologically acceptable salts or solvates as therapeutically active substances eliciting the selective affinity to 5-HT6 receptors. Invention relates also to a pharmaceutical preparation eliciting effect of agonist of 5-HT6 receptors and comprising at least one compound of the formula (I) or one of its physiologically acceptable salts or solvates. Proposed sulfonyloxazoloamines can be used as therapeutically active substances eliciting the selective affinity to 5-HT6 receptors.

EFFECT: valuable medicinal and pharmacological properties of compounds.

3 cl, 19 ex