N-SUBSTITUTED 1H-INDOLE-5-PROPIONIC ACIDS, PHARMACEUTICAL COMPOSITION CONTAINING THESE COMPOUNDS AND THEIR USING (VARIANTS) Russian patent published in 2007 - IPC C07D413/06 C07D413/14 C07D417/06 A61K31/405 A61P3/06 A61P3/10 A61P9/10 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds represented by the general formula (I): and their pharmaceutically acceptable salts and esters possessing agonistic activity with respect to peroxisome proliferator receptors PPARα and/or PPARγ, to a pharmaceutical composition based on thereof and their using for preparing medicines wherein R¹ means thiophenyl or phenyl optionally substituted with from one to three substitutes chosen independently from halogen atom, (C₁-C₈)-alkoxy-group, (C₁-C₈)-alkyl and (C₁-C₈)-alkyl substituted with one-three halogen atoms; R² means hydrogen atom or (C₁-C₈)-alkyl; R³ means phenoxy-, (C₂-C₈)-alkenyloxy- or (C₁-C₈)-alkoxy-group; R⁴ means hydrogen atom or (C₁-C₈)-alkyl wherein one of substitutes R⁵ and R⁶ means compound of the formula and another one means hydrogen atom and wherein the bond between carbon atoms C^a and C^b means a carbon-carbon simple or double bond; R⁷ means hydrogen atom or (C₁-C₈)-alkyl; R⁸ means hydrogen atom or (C₁-C₈)-alkyl being any of A and A¹ means nitrogen atom and another means oxygen or sulfur atom; n means 1, 2 or 3.

EFFECT: valuable medicinal properties of compound and pharmaceutical composition.

30 cl, 1 tbl, 14 sch, 86 ex