FUROPYRIDINE ARALKYLAMINES, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE SUBSTANCES Russian patent published in 2004 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to compounds of the formula (I):

wherein NRR₁ is joined at position 5 or 6 of furopyridine ring; R represents hydrogen atom, (C₁-C₄)-alkyl or COR₂; R₁ represents (CH₂)_nAr, CH₂CH=CHAr or CH₂C≡CAr; n = 0-3; A represents nitrogen atom or NO; Ar represents 5- or 6-membered aromatic or heteroaromatic ring that comprises 0-4 nitrogen atoms, 0-1 oxygen atom and 0-1 sulfur atom; or 8-, 9- or 10-membered condensed aromatic or heteroaromatic cyclic system comprising 0-4 nitrogen atoms, 0-1 oxygen atom and 0-1 sulfur atom and any of that can be, optionally, substituted with 1-2 substituents taken independently among halogen atom, trifluoromethyl or (C₁-C₄)-alkyl; R₂ represents hydrogen atom, (C₁-C₄)-alkyl, (C₁-C₄)-alkoxy-group or phenyl ring optionally substituted with 1-3 following substituents : halogen atom, (C₁-C₄)-alkyl, (C₂-C₄)-alkenyl, (C₂-C₄)-alkynyl, OH, (OC₁-C₄)-alkyl, CO₂R₅, -CN, -NO₂, -NR₃R₄ or -CF₃; R₃, R₄, R₅ can mean hydrogen atom, (C₁-C₄)-alkyl or phenyl ring optionally substituted with 1-3 following substituents: halogen atom, (C₁-C₄)-alkyl, (C₂-C₄)-alkenyl, (C₂-C₄)-alkynyl, OH, (OC₁-C₄)-alkyl, -CN, -NO₂ or -CF₃; to their enantiomers and pharmaceutically acceptable salts. Prepared compounds elicit agonistic activity with regards to nicotine receptors of acetylcholine and can be used for treatment or prophylaxis of psychotic disorders or disorders of mental capacity.

EFFECT: improved preparing method, valuable medicinal and pharmacological properties of compounds.

27 cl, 1 tbl, 36 ex