FIELD: chemistry.
SUBSTANCE: invention relates to compounds of general formula (I)
where R1 is halogen, m is 1, 2 or 3; n is 1, 2 or 3; Ar is a six-membered heteroaryl group selected from
and 
where R2 is hydrogen, C1-4 alkyl or C1-4 alkoxy; R3 is hydrogen; or a pharmaceutically acceptable salt thereof, a method of producing a pharmaceutical composition, use of the compound for preparing a drug for modulating gamma-secretase activity and a method for modulating gamma-secretase activity.
EFFECT: novel compounds which can be used to modulate gamma-secretase activity are obtained.
30 cl, 1 tbl, 64 ex
| Title |
Year |
Author |
Number |
| BICYCLIC HETEROARYL DERIVATIVES |
2019 |
- Ratni, Khasan
- Karter, Dzhennifer Luiz
|
RU2815806C2 |
| PYRIDAZINE DERIVATIVES AS RORc MODULATORS |
2017 |
- Bronner, Sara M.
- Krouford, Dzhejms Dzh.
- Kridlend, Endryu
- Ser, Patrik
- Fauber, Bendzhamin
- Gansiya, Emanuela
- Gobbi, Alberto
- Kherli, Kristofer
- Killen, Dzhonatan
- Li, Vendi
- Rene, Olive
- Van Nil, Monik Bodil
- Uord, Styuart
- Uinship, Pol
- Zbig, Dzhejson
|
RU2757571C2 |
| HER2 MUTATION INHIBITORS |
2022 |
- Ellis, Bryan Daniel
- Hicken, Erik James
- Laird, Ellen Ruth
- Lazzara, Nicholas Charles
- Newhouse, Bradley Jon
- Pajk, Spencer Phillip
- Rosen, Rachel Zoe
- Shelp, Russell Andrew
|
RU2834124C2 |
| SECONDARY AMINES AS RENIN INHIBITORS |
2007 |
- Betsenkon Oliv'E
- Bur Daniel'
- Korminbef Oliv'E
- Djub Daniel'
- Grizostomi Korinna
- Makdonal'D Duajt
- Makkej Dehn
- Pauehll Dehvid
- Remen Ljubosh
- Rishar-Bildstejn Sil'Vija
- Shajgetts Dzhon
- Ter'En Mishel'
- Veller Tomas
|
RU2425032C2 |
| CONDENSED TRICYCLIC BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY |
2014 |
- Aleksander Rikki Piter
- Kalmiano Mark Daniel
- Defejs Sabine
- Dyure Veronik
- Delini Mikhael
- Kher Yag Paul
- Dzhekson Viktoriya Elizabet
- Keje Zhan
- Kroplin Boris
- Mak-Koss Malkolm
- Sabnis Jogesh Anil
- Selbi Mattyu Dankan
- Svinnen Dominik Lui Leon
- Van-Khautvin Natali
- Chzhu Chzhaonin
- Vener Folkmar
- Khajnelt Uve
|
RU2689777C1 |
| DNA-DEPENDENT PROTEIN KINASE INHIBITOR |
2020 |
- Qi Changhe
- Tsui Honchung
- Zeng Qingbei
- Yang Zhenfan
- Zhang Xiaolin
|
RU2835434C2 |
| AMINOPYRIDINE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS |
2022 |
- Li, Jialiang
- Arista, Luca
- Babu, Sreehari
- Bian, Jianwei
- Cui, Kai
- Dillon, Michael Patrick
- Lattmann, Rene
- Liao, Lv
- Lizos, Dimitrios
- Ramos, Rita
- Stiefl, Nikolaus Johannes
- Ullrich, Thomas
- Usselmann, Peggy
- Wang, Xiaoyang
- Waykole, Liladhar Murlidhar
- Weiler, Sven
- Zhang, Yubo
- Zhou, Yizong
- Zhu, Tingying
|
RU2803084C1 |
| FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY |
2014 |
- Aleksander Rikki Piter
- Brejs Garet Nil
- Braun Dzhulien Alister
- Kalmiano Mark Daniel
- Chovatiya Praful Tulshi
- Delini Mikhael
- Gallimor Ellen Oliviya
- Kher Yag Paul
- Dzhekson Viktoriya Elizabet
- Kroplin Boris
- Mak-Koss Malkolm
- Kuinsi Dzhoanna Rejchel
- Sabnis Jogesh Anil
- Svinnen Dominik Lui Leon
- Chzhu Chzhaonin
- Khajnelt Uve
- Vener Folkmar
|
RU2679914C9 |
| AMINOPYRIDINE DERIVATIVES AND APPLICATION THEREOF AS SELECTIVE ALK-2 INHIBITORS |
2017 |
- Li, Tszyalyan
- Arista, Luka
- Babu, Srikhari
- Byan, Tszyanvej
- Tsuj, Kaj
- Dillon, Majkl Patrik
- Lattmann, Rene
- Lyao, Lv
- Lizos, Dimitrios
- Ramos, Rita
- Shtifl, Nikolaus Jokhannes
- Ullrikh, Tomas
- Usselmann, Peggi
- Van, Syaoyan
- Vajkole, Liladkhar Murlidkhar
- Vajler, Sven
- Chzhan, Yujbo
- Chzhou, Itszun
- Chzhu, Tinin
|
RU2777979C2 |
| PHARMACEUTICAL COMPOUNDS |
2019 |
- Johnson Christopher Norbert
- Buck Ildiko Maria
- Chessari Gianni
- Day James Edward Harvey
- Fujiwara Hideto
- Hamlett Christopher Charles Frederick
- Hiscock Steven Douglas
- Holvey Rhian Sara
- Howard Steven
- Liebeschuetz John Walter
- Palmer Nicholas John
- St Denis Jeffrey David
- Twigg David Geoffrey
- Woodhead Andrew James
|
RU2821941C2 |
