SPIROAZOBICYCLIC HETEROCYCLIC COMPOUNDS, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, heterocyclic compounds, pharmacy. SUBSTANCE: invention relates to novel biologically active compounds, namely, spiroazobicyclic heterocyclic compounds of the formula (I): where n = 0 or 1; m = 0 or 1; p = 0; X presents oxygen or sulfur atom; Y presents CH, N or NO; W presents oxygen atom or H₂; A presents N or C(R²); G presents N or C(R³); D presents N or C(R⁴) under condition that only one among A, G and D presents nitrogen atom but at least one among Y, A, G and D presents nitrogen atom or NO; R¹ presents hydrogen atom or C₁-C₄-alkyl; R², R³, R⁴ present independently hydrogen, halogen atom, C₁-C₄-alkyl, C₂-C₄-alkenyl, C₂-C₄- alkynyl, aryl, heteroaryl including 5- or 6-membered aromatic ring with 1 or 2 nitrogen atoms and also furyl or morpholyl, OH, OC₁-C₄-alkyl, CO₂R¹, - CN, -NO₂, -NR⁵R⁶; or R² and R³ or R³ and R⁴, respectively, can form in common with A and G or G and D, respectively, another 6-membered aromatic ring; R⁵ and R⁶ present independently hydrogen atom, C₁-C₄-alkyl, and phenyl or they can present in common (CH₂)_jQ(CH₂)_k where Q means linkage; j = 2; k = 0-2; R⁷, R⁸, R⁹, R¹⁰ present independently C₁-C₄4-alkyl, NH₂, aryl or its enantiomer; and their pharmaceutically acceptable salts. Invention relates also to methods of their synthesis, intermediate compounds and pharmaceutical composition that shows activating effect with regards to nicotine α7-receptors of acetylcholine and can be used in treatment and prophylaxis of psychotic disturbances or attenuation of mental activity. Invention provides synthesis of novel compounds eliciting valuable biological and medicinal properties. EFFECT: improved methods of synthesis. 17 cl, 43 ex