METHOD FOR PREPARING 10-(2,3,4-TRIMETHOXY-6-METHYLPHENYL)-DECANOIC ACID ETHYL ESTER Russian patent published in 2004 - IPC

Abstract RU 2233833 C1

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to the improved method for preparing 10-(2,3,4-trimethoxy-6-methylphenyl)-decanoic acid ethyl ester that is a semi-finished product used for synthesis of idebenone that represents a medicinal drug with nootropic effect. Method involves hydrogenation of 9-(2,3,4-trimethoxy-6-methylbenzoyl)-nonanoic acid ethyl ester with hydrogen in medium of organic solvent - lower monohydric alcohol in the presence of palladium catalyst on carbon-containing carrier "Sybunit" treated preliminary with sulfuric acid isopropanol solution with the concentration 0.36 x 10^-2 kmole/m³. The hydrogenation reaction is carried out on the stationary catalyst and 9-(2,3,4-trimethoxy-6-methylbenzoyl)-nonanoic acid ethyl ester solution is fed continuously to the reaction zone in the amount (1.66 x 10^-2) - (8.3 x 10^-2) kmole/m³, and hydrogen is fed under the pressure 0.5-6.0 MPa at the feeding rate (0.5 x 10^-8) - (12.0 x 10^-8) m³/s. Owing to the development of the continuous method the intensification of process is provided with preparing large amounts of the end product.

EFFECT: improved preparing method.

3 cl, 1 dwg, 4 ex

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RU 2 233 833 C1

Authors

Sul'Man Eh.M.

Shkileva I.P.

Dates

2004-08-10—Published

2003-04-29—Filed