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Application

2002134821/04, 2002-12-25

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Start date

2002-12-25

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Actual filing date

2002-12-25

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Published

2004-08-20

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Inventor

Kazankov M.V.Beljakov N.G.Nikolaev Ju.T.Kosmynina G.V.Egorova T.P.Zotova O.A.Sidorenko E.N.Dutova T.Ja.Krylova E.K.Tishchenko I.E.

(73)

Holder

Federal'Noe Gosudarstvennoe Unitarnoe Predprijatie Nauchnyj Tsentr Institut Organicheskikh Poluproduktov I Krasitelej"

METHOD FOR PREPARING 1-(2,3,4-TRIMETHOXYBENZYL)-PIPERAZINE DIHYDROCHLORIDE Russian patent published in 2004 - IPC

Abstract RU 2234501 C1

FIELD: organic chemistry, chemical technology, pharmacy.

SUBSTANCE: invention relates to synthesis of medicinal substances, namely, to preparing 1-(2,3,4-trimethoxybenzyl)-piperazine dihydrochloride (I) that represents a component of the medicinal preparation trimetazidine. The compound (I) is prepared by interaction of 2,3,4-trimethoxybenzaldehyde with piperazine by catalytic hydrogenation with hydrogen on palladium on carbon as a catalyst at temperature 80-85 C wherein 2,3,4-trimethoxybenzaldehyde is added to reaction gradually. Also, the reaction can be carried out in the presence of catalytic amounts of acetic acid. Method can be utilized in the industrial scale.

EFFECT: improved preparing method.

3 ex

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RU 2 234 501 C1

Authors

Kazankov M.V.

Beljakov N.G.

Nikolaev Ju.T.

Kosmynina G.V.

Egorova T.P.

Zotova O.A.

Sidorenko E.N.

Dutova T.Ja.

Krylova E.K.

Tishchenko I.E.

Dates

2004-08-20—Published

2002-12-25—Filed