FIELD: organic chemistry, biochemistry, chemical technology, pharmacy.
SUBSTANCE: invention relates to new derivatives of lipoic acid of the formula (Ia): 
wherein A means radicals -(CH2)m-CO-NR3-(CH2)n- or -(CH2)m-; R3 means hydrogen atom or radical (C1-C6)-alkyl; X means radical of the formula: 
wherein T in common with Y means radical -(CH2)I-; R5 means alkyl radical, alkoxy-group, dialkylamino-group, 5-membered heterocycle. Compounds elicit inhibitory effect with respect to activity of NO-synthases producing nitrogen monoxide NO, and/or they are agents allowing regeneration of antioxidants. Invention relates also to methods for preparing these compounds, pharmaceutical preparations comprising thereof and their application for therapeutic aims.
EFFECT: improved preparing method, valuable biological and medicinal properties of compounds.
8 cl, 10 ex
| Title |
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