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2 238 939

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C2

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IPC

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Application

2001111022/04, 1999-09-22

(24)

Start date

1999-09-22

(22)

Actual filing date

1999-09-22

(45)

Published

2004-10-27

(72)

Inventor

Ovehn SerzhShabrie De Ljason'Er P'Er-Eht'EnnArnet ZheremiaPon DominikJulibarri Zherar

(73)

Holder

Sos'Ete De Konsej De Reshersh Eh D'Applikas'On S'Entifik

DERIVATIVES OF AMIDINES, COMPOUNDS, PHARMACEUTICAL COMPOSITION Russian patent published in 2004 - IPC

Abstract RU 2238939 C2

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to new derivatives of amidine of the general formula (I'):

wherein A represents radical of the formula:

wherein R1, R2 and R3 mean OH or (C1-C6)-alkyl, (C1-C6)-alkoxy-group; R4 means hydrogen atom (H), (C1-C6)-alkyl; R5 means hydrogen atom (H), (C1-C6)-alkyl or radical of the formul

wherein R10, R11 and R12 mean OH or hydrogen atom (H); R13 means hydrogen atom (H), (C1-C6)-alkyl or radical of the formula:

wherein R18, R19 and R20 mean hydrogen atom (H), (C1-C6)-alkyl; R21 and R22 mean hydrogen atom (H), (C1-C6)-alkyl; or R21 means alkylsulfonyl, alkylsulfoxide, alkylcarbonyl; R22 means hydrogen atom (H) or radical of the formula:

wherein T means (CH2)k- wherein k = 1, 2; R27 means hydrogen atom (H), (C1-C6)-alkyl. Compounds elicit the inhibitory ability with respect to NO-synthase and lipid peroxidation.

EFFECT: valuable biological and biochemical properties of compounds.

13 cl, 24 sch, 82 ex

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RU 2 238 939 C2

Authors

Ovehn Serzh

Shabrie De Ljason'Er P'Er-Eht'Enn

Arnet Zheremia

Pon Dominik

Julibarri Zherar

Dates

2004-10-27—Published

1999-09-22—Filed

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