FIELD: organic chemistry, vitamins, pharmacy.
SUBSTANCE: invention relates to compounds of the general formula (I):
wherein R1 means hydrogen atom, radical CH3 or radical (CH2)OH; R2 means radical (CH2)OH; X-Y means a bond or
; Z means a cycle taken among cycles of the following formulas:
or
; R3 means alkyl chain with 4-8 carbon atoms substituted with one or some hydroxyl groups and, except for, substituted with one or some lower alkyl groups, and/or substituted with one or some halogen atom, and/or substituted with one or some groups CF3, and/or wherein one or some simple bonds in chain can be replaced for one or some double bonds being R in cycle is in para- or meta-position with regards to the bond X-Y; and also to optical and geometrical isomers of above indicated compound of the formula (I). Invention relates also to pharmaceutical and cosmetic compositions. Invention provides preparing structural analogues of vitamin D that elicit selective activity with regards of cellular proliferation and cellular differentiation being without manifestation of hypercalcienic effect and these compounds can be synthesized easily.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
9 cl, 6 dwg, 17 ex
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Authors
Dates
2004-08-20—Published
2000-11-22—Filed