FIELD: organic chemistry, medicine, cosmetology.
SUBSTANCE: invention relates to new triaromatic analogs of vitamin D of the general formula (I):
wherein R1 means -CH3 or -CH2-OH; R2 means -CH2-OH; X-Y is a bind of formulas (a)
or (c) 
wherein R6 means hydrogen atom (H), lower alkyl; W means oxygen (O), sulfur (S) atom or -CH2-; Ar1 and Ar2 mean cycles of formula
wherein R8, R9, R11, R12 mean hydrogen, halogen atom, OH, CF3; R3 means
wherein R13, R14 means lower alkyl, CF3; R15 means hydrogen atom (H), acetyl, trimethylsilyl, tetrahydropyranyl, or their salts. Compound of the formula (I) are useful in treatment of dermatological diseases associated with disturbances in keratinization.
EFFECT: valuable medicinal and cosmetic properties of compounds.
11 cl, 1 tbl, 6 dwg, 31 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANALOGS OF VITAMIN D | 2002 |
|
RU2301794C2 |
| 2,5-DIOXOIMIDAZOLIN-4-YL METHYLCARBONYL COMPOUNDS, METHOD OF OBTAINING THEM, PHARMACEUTICAL MIXTURES CONTAING THEM AND THIR USE IN MEDICINE PREPARATION | 2003 |
|
RU2326117C2 |
| BRUTON'S TYROSINE KINASE INHIBITORS | 2010 |
|
RU2542585C2 |
| CATECHOL-O-METHYL TRANSFERASE INHIBITORS AND USE THEREOF IN TREATING PSYCHOTIC DISORDERS | 2011 |
|
RU2586974C2 |
| POLYCYCLIC DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR PHARMACEUTICAL APPLICATION | 2012 |
|
RU2621039C1 |
| DERIVATIVES OF THIOPHEN AND PHARMACEUTICAL COMPOSIITON (VERSIONS) | 2003 |
|
RU2359967C2 |
| BIARYLOXYMETHYLARENE CARBOXYLIC ACIDS | 2004 |
|
RU2373187C2 |
| VIRAL REPLICATION INHIBITORS, METHOD FOR PRODUCTION THEREOF AND THERAPEUTIC APPLICATIONS THEREOF | 2014 |
|
RU2678575C2 |
| NOVEL PHENYLPYRAZINONES AS KINASE INHIBITORS | 2009 |
|
RU2507202C2 |
| COMT INHIBITORS | 2013 |
|
RU2642779C2 |
