FIELD: organic chemistry, chemical technology, biochemistry.
SUBSTANCE: invention relates to methods for separation of mixture of enantiomers of cis-2-hydroxymethyl-5-(5-fluorocytosine-1-yl)-1,3-oxathiolan. Methods involve passing a mixture through cyclodextrin-bound chiral column, selective hydrolysis of 5'-O-acyl derivative of nucleoside using enzymes and selective deamination of mixture of enantiomers using cytidine deaminase.
EFFECT: improved separating methods.
12 cl, 11 tbl, 12 dwg, 12 ex
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