FIELD: chemistry.
SUBSTANCE: disclosed is a method of producing 1,3-oxathiolane nucleosides, which involves reaction of (5-acetyloxy-1,3-oxathiolan-2-yl)methyl butanoate with a silylated pyrimidine or purine base in the presence of TiCl3(isopropoxide). Said reaction enables to obtain a product mainly containing β anomer.
EFFECT: efficient method of producing 1,3-oxathiolane nucleosides.
13 cl, 3 dwg, 16 ex
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