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2 236 250

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IPC

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Application

98121135/15, 1997-04-24

(24)

Start date

1997-04-24

(22)

Actual filing date

1997-04-24

(45)

Published

2004-09-20

(72)

Inventor

B'Ern SerenSerensen Khans Khol'MegorLangballe PeterLarsen Sil'Ke MellerEhbbekhej KirstenKhansen Birte Ljukkegor

(73)

Holder

Novo Nordisk A/S

PHARMACEUTICAL COMPOSITION COMPRISING GROWTH HORMONE, AMINO ACID AND NON-IONIC DETERGENT Russian patent published in 2004 - IPC

Abstract RU 2236250 C2

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to an aqueous pharmaceutical composition comprising human growth hormone, amino acid histidine, and non-ionic detergent poloxamer-188. Composition is stabilized against desamidation and aggregation and mannitol is added for isotonicity, and phenol; pH value of the composition is 6.0-6.3. Invention provides enhancing the stability of composition.

EFFECT: improved and valuable pharmaceutical properties of composition.

5 cl, 4 tbl, 4 ex

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RU 2 236 250 C2

Authors

B'Ern Seren

Serensen Khans Khol'Megor

Langballe Peter

Larsen Sil'Ke Meller

Ehbbekhej Kirsten

Khansen Birte Ljukkegor

Dates

2004-09-20—Published

1997-04-24—Filed

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