FIELD: chemistry of metal-complex compounds, medicine, oncology.
SUBSTANCE: invention relates to new compounds of metal-complexes of carboranylporphyrins of the general formula (I):
wherein (Ia): R is H; R1 = R3 = R5 = R8 is CH3; R2 = R4 is -CH=CH2; R6 = R7 is m-C2B10H11-CH2-COO-(CH2)2-; M is Fe+; (Ib): R is H; R1 = R3 = R5 = R8 is CH3; R2 = R4 is -CH=CH2; R6 = R7 is o-C2B10H11-NH-CO-(CH2)2-; M is Fe+; (Ic): R is H; R1 = R3 = R5 = R8 is CH3; R2 = R4 is -CH=CH2; R6 = R7 is o-C2B9H11-NH-CO-(CH2)2- -(C4H9)4N+; M is Fe+; (Id): R is H; R1 = R3 = R5 = R8 is CH3; R2 = R4 is -CH=CH2; R6(R7) is -(CH2)2-COO-CH2-CB11H11; R7(R6) is -CH2CH2COOH; M is Fe+; (Ie): R is H; R1 = R3 = R5 = R8 is CH3; R2 = R4 is -CH=CH2; R6(R7) is -(CH2)-COO-CH(C6H5)-CB11H11; R7(R6) is -CH2CH2COOH; M is Fe+; (If): R is H; R1 = R3 = R5 = R8 is CH3; R2 = R4 is -CH=CH2; R6(R7) is o-C2B10H11-NH-CO-(CH2)2-; R7(R6) is -(CH2)2-COO-CH2-CB11H11; M is Fe+; (Ig): R is C6H5; R1 is o-CH3-CB10H10-C-CH(OH)-; R2 = R3 = R4 = R5 = R6 = R7 = R8 is H; M is Cu; (Ih): R is C6H5; R1 is m-C3H7-CB10H10-C-CH(OH)-; R2 = R3 = R4 = R5 = R6 = R7 = R8 is H; M is Cu; (Ii): R is C6H5; R1 is o-CH3-CB10H10-C-CH(OH)-; R2 = R3 = R4 = R5 = R6 = R7 = R8 is H; M is Co; (Ij): R is C6H5; R1 is m-C3H7-CB10H10-C-CH(OH)-; R2 = R3 = R4 = R5 = R6 = R7 = R8 is H; M is Co; (Ik): R is C6H5; R1 is o-CH3-CB10H10-C-CH(OH)- -(C4H9)4N+; R2 = R3 = R4 = R5 = R6 = R7 = R8 is H; M is Cu; (Il): R is C6H5; R1 is m-C3H7-CB10H10-C-CH(OH)- -(C4H9)4N+; R2 = R3 = R4 = R5 = R6 = R7 = R8 is H; M is Co. These compounds elicit antitumor activity and show low toxicity and can be used in boron-neutron-capture cancer therapy.
EFFECT: valuable medicinal properties of compounds.
1 cl, 3 dwg, 3 ex
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