CARBORANYL DERIVATIVES OF FLOURINATED PORPHYRINS AND METAL COMPLEXES THEREOF, HAVING PHOTOSENSITISER PROPERTIES, AND SYNTHESIS METHOD THEREOF Russian patent published in 2010 - IPC C07D487/22 C07F5/02 A61K31/409 

Abstract RU 2402554 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a novel carboranyl derivative of fluorinated porphyrins of general formula I , where Ia: M=2H, R=o-CB10H10C-, Ib: M=2M, R=o-C6H5-CB10H10C-, Ic: M=2H, R=-CB11H11-Cs+, Id: M=Cu, R=-CB11H11-Cs+, Ie: M=Pd, R=-CB11H11-Cs+, If: M=2H, R=-CB11H11-Na+, Ig: M=Cu, R=-CB11H11-Na+, Ih: M=Pd, R=-CB11H11-Na+,having photosensitiser properties. The invention also discloses methods for synthesis of said compounds.

EFFECT: compounds which exhibit photosensitiser properties can be used in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) of oncological diseases.

6 cl, 8 ex, 1 tbl

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RU 2 402 554 C2

Authors

Ol'Shevskaja Valentina Antonovna

Zajtsev Andrej Viktorovich

Kalinin Valerij Nikolaevich

Chkanikov Nikolaj Dmitrievich

Sigan Andrej Lejzorovich

Shtil' Aleksandr Al'Bertovich

Dates

2010-10-27Published

2008-07-17Filed