METHOD OF PRODUCING BORATED PORPHYRINS Russian patent published in 2015 - IPC C07F5/02 C07D403/14 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing carbonyl derivatives of 5,10,15,20-tetraphenylporphyrin of formula I where R is o-carborane or m-carborane, which are obtained by reacting mercaptocarborane with 5,10,15,20-tetra(n-trifluoromethanesulphonylmethyloxyphenyl)porphyrin in palladium catalysis conditions while boiling in anhydrous toluene while stirring in an atmosphere of an inert gas at room temperature. The method includes successively adding diisopropylethylamine (DIPEA), the corresponding mercaptocarborane, 1,1'-bis(diphenyl-phosphino)ferrocene (dppf) and tris(dibenzylideneacetone)dipalladium (Pd₂(dba)₃), followed by boiling the reaction mixture in an Ar atmosphere for a few hours, separating the finished products using know techniques; 5,10,15,20-tetra(n-trifluoromethanesulphonylmethyloxyphenyl)porphyrin is obtained by reacting 5,10,15,20-tetrahydroxyporphyrin with a trifluoromethanesulphonic acid anhydride in a medium of methylene chloride in an atmosphere of an inert gas.

EFFECT: obtaining novel carbonyl derivatives of 5,10,15,20-tetraphenylporphyrin, which can be used as anti-tumour agents in boron neutron capture therapy and photodynamic therapy of cancerous diseases.

1 dwg, 2 ex