CARBORANYLPORPHYRINE AND USE THEREOF Russian patent published in 2013 - IPC A61N5/10 A61K31/555 A61K31/69 A61K31/409 C07F5/02 C07F1/08 C07D487/22 

FIELD: medicine.

SUBSTANCE: present invention refers to a boron-containing compound of formula: wherein R¹, R², R³ and R⁴ independently mean -NO₂, halogen or a substitute presented by the following formula wherein the substitutes Y are independently found in an ortho-, meta- or para- position on a phenyl ring, and independently mean hydrogen or a substitute presented by formula : provided at least one of R¹, R², R³ and R⁴ means a substitute presented by formula (2) wherein Y is presented by formula (3); wherein: X means oxygen or sulphur; R¹⁰ and R¹¹ are independently specified in hydrogen and C₁-C₄ hydrocarbonyl; Z means a carborane cluster containing at least two carbon atoms and at least three boron atoms, or at least one carbon atom or at least five boron atoms in a frame structure; r means 0 or an integer within 1 to 20; a means an integer within 1 to 4; and also provided at least one of R¹, R², R³ and R⁴ means a substitute presented by -NO₂ or halogen; and M means either two hydrogen ions, or a two-valence metal ion, a three-valence metal ion, a four-valence metal ion with a charge of the porphirine-metal complex formed by the three-valence or four-valence metal ion being neutralised by a corresponding number of counteranions, dianions. There are also presented a method for visualising a tumour and surrounding tissues, and a method for bimodal therapy of cancer.

EFFECT: invention provides preparing carboranylporphyrines with a prolonged tumour time selectively targeted on tumour cells and destructing them with minimal involvement of healthy tissues.

24 cl, 4 tbl, 12 ex