FIELD: biotechnology, genetic engineering, medicine, biochemistry.
SUBSTANCE: invention relates to identification and characterization of two components of recombinant DNA-ase preparation. These components represent the purified desamidated and purified non-desamidated human DNAa-ase. Methods for separation of these DNA-ases involve using polydentate cation-exchange resin or using heparin immobilized on this resin, or non-hydrolyzable DNA analog immobilized on this resin. The use of non-desamidated DNA-ase as a component of the pharmaceutical composition is effective for administration to patients suffering with disturbances in pulmonary system.
EFFECT: improved separating method, improved treatment method, valuable medicinal properties of composition.
14 cl, 10 dwg, 3 tbl, 1 ex
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