FIELD: molecular biology.
SUBSTANCE: method involves bombarding layer of substance under study deposited on substrate, with accelerated nanocluster metal ions. Bombarding particles kinetic energy variable over wide range is liberated as a result of elastic impact with molecules of substance under study and substrate atoms. Desorbed molecular ions are recorded with time-of-flight mass spectrometer. The time-of-flight mass specters obtained in self-superposition mode show that the nanoions of 107 amu mass and energy of 220 keV are capable of desorbing biomolecular ions of several thousand atomic mass units.
EFFECT: higher upper limit of measurable biomolecule mass; improved sensitivity of the method.
2 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING METALLIC NANOCLUSTERS IN FREE STATE | 2007 |
|
RU2341845C2 |
| DEVICE FOR PRODUCING LIQUID-METAL NANOCLASTER ION BEAMS | 2001 |
|
RU2210135C2 |
| DEVICE FOR GENERATING BEAMS OF ACCELERATED NANO-CLUSTER IONS | 2010 |
|
RU2423753C1 |
| METHOD OF DE-SORPTION/IONIZATION OF CHEMICAL COMPOUNDS | 2005 |
|
RU2285253C1 |
| BIOMOLECULAR SENSOR WITH A MICROELECTRONIC GENERATOR OF AN ELECTROMAGNETIC WAVE | 2020 |
|
RU2749698C1 |
| METHOD OF SECONDARY-ION MASS-SPECTROMETRY OF SOLID | 0 |
|
SU708794A1 |
| METHOD OF DETERMINING METALS AND METAL COMPLEXES | 2013 |
|
RU2531762C1 |
| METHOD OF CONTROLLING RELATION OF RESOLUTION ABILITY BY WEIGHT AND SENSITIVITY IN MULTI-REFLECTIVE TIME-OF-FLIGHT MASS-SPECTROMETERS | 2015 |
|
RU2660655C2 |
| METHOD FOR IDENTIFYING SEROVARS OF LEPTOSPIRA BACTERIA USING MALDI-TOF SPECTROMETRY | 2017 |
|
RU2661108C1 |
| METHOD OF ANALYSING MIXTURES OF CHEMICAL COMPOUNDS BASED ON SEPARATION OF IONS OF SAID COMPOUNDS IN LINEAR RADIO FREQUENCY TRAP | 2012 |
|
RU2502152C2 |
