FIELD: organic chemistry, medicine, oncology, biochemistry.
SUBSTANCE: invention proposes applying inhibitors of cyclooxygenase-2 of the general formula (II) 
wherein R4, R2 and R3 are given in the invention description used for treatment and prophylaxis of neoplasia, in particular, adenomatous polyps, digestive tract cancer, liver cancer, skin cancer, bladder cancer, uterus cervix cancer, prostate gland cancer and lung cancer and a medicinal agent based on thereof.
EFFECT: expanding assortment of agents of indicated designation, valuable medicinal properties of inhibitors.
20 cl, 2 tbl
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| 2-CYCLOOXYGENASE INHIBITORS AS ANTIANGIOGENIC AGENTS | 1997 |
|
RU2268716C2 |
| PHARMACEUTICAL COMPOSITION FOR USING IN THERAPY OF MALIGNANT NEOPLASM COMPRISING COMBINATION OF BISPHOSPHONATE, COX-2 INHIBITOR AND TAXOL | 2002 |
|
RU2317819C2 |
| PYRAZOLYL-SUBSTITUTED BENZENESULFONEAMIDE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF TREATMENT OF PATIENTS WITH INFLAMMATION OR INFLAMMATION-ASSOCIATED DISEASES | 1994 |
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RU2139281C1 |
| METHOD FOR TREATING INFLAMMATION OR INFLAMMATION-INDUCED DISEASE IN DOGS | 1996 |
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RU2253456C2 |
| SUBSTITUTED ISOXAZOLES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INFLAMMATION SUPPRESSION | 1996 |
|
RU2200158C2 |
| NOVEL HETEROCYCLES | 2009 |
|
RU2572616C2 |
| 2-ARYL-SUBSTITUTED N-ARYLIMIDAZOLINES, SELECTIVE CYCLOOXYGENASE-2 INHIBITORS, METHODS FOR PRODUCTION AND USE THEREOF | 2014 |
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RU2565667C1 |
| DERIVATIVES OF PYRAZOLINE, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION | 1999 |
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RU2233272C2 |
| METHOD OF SYNTHESIS OF PYRAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2021990C1 |
| NOVEL 1,2-BIS-SULPHONAMIDE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR | 2011 |
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