PYRAZOLYL-SUBSTITUTED BENZENESULFONEAMIDE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF TREATMENT OF PATIENTS WITH INFLAMMATION OR INFLAMMATION-ASSOCIATED DISEASES Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to pyrazolyl-substituted benzenesulfoneamide of the formula (I) where R¹ - phenyl that has a substituent at position that can be substituted as a single radical taken among of halogen atom, (C₁-C₁₀)-alkyl, sulfamylic group or the group (a) ; R² - hydrogen atom, (C₁-C₁₀)-alkyl, (C₁-C₆)-halogenalkyl, cyano-group, carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-carboxyalkyl, (C₁-C₁₀)-cyanoalkyl, (C₁-C₆)-alkoxycarbonylcyano-(C₂-C₆)-alkenyl, aminocarbonyl, (C₁-C₆)-amino- -carbonylalkyl, (C₁-C₆)-N-alkylaminocarbonyl, N-arylaminocarbonyl, (C₃-C₇)-cycloalkylaminocarbonyl, (C₁-C₆)-carboxyalkylaminocarbonyl, (C₁-C₆)-aralkoxycarbonyl-(C₁-C₆)-alkylaminocarbonyl, (C₁-C₆)-hydroxyalkyl (values of other radicals are given in p. 1 of the invention claim). Compounds of the formula (I) are useful for treatment of patients with vascular diseases, migraine, thyroid gland inflammation. EFFECT: enhanced effectiveness of compounds. 19 cl, 12 tbl, 262 ex